--- title: 3D Gaussian Splatting and Future Digital Twins description: Demonstration of 3D Gaussian Splatting with optical phantom technology to create detailed digital twins for accelerating fluorescence imaging development. image: https://blog.quelimaging.com/hubfs/QUEL_FluoFlowColon.gif --- [Skip to content](https://blog.quelimaging.com/3dgs-opsiclear-quel#main-content) [![QUEL_web_logo-1](https://blog.quelimaging.com/hs-fs/hubfs/QUEL_web_logo-1.png?width=320&height=120&name=QUEL_web_logo-1.png)](https://shop.quelimaging.com/) - [Home](https://www.quelimaging.com/) - [Products](https://shop.quelimaging.com/) - [Blog](https://blog.quelimaging.com/) - [News](https://www.quelimaging.com/news) - [About](https://www.quelimaging.com/about) Open main navigation Close main navigation - [Home](https://www.quelimaging.com/) - [Products](https://shop.quelimaging.com/) - [Blog](https://blog.quelimaging.com/) - [News](https://www.quelimaging.com/news) - [About](https://www.quelimaging.com/about) - [Contact us](https://share.hsforms.com/1qlwaYoKVQvGnvWZt0GNGagcxyzv) [Contact us](https://share.hsforms.com/1qlwaYoKVQvGnvWZt0GNGagcxyzv) ### View of Field Nov 14, 2025 10:45:00 AM # 3D Gaussian Splatting and Future Digital Twins ![Picture of Ethan LaRochelle](https://app.hubspot.com/settings/avatar/925081a77283a399dbd145b49b251212) [Ethan LaRochelle](https://blog.quelimaging.com/author/ethan) Share: [facebook-f icon](http://www.facebook.com/share.php?u=https://blog.quelimaging.com/3dgs-opsiclear-quel) [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.quelimaging.com/3dgs-opsiclear-quel) [Twitter icon](https://twitter.com/intent/tweet?url=https://blog.quelimaging.com/3dgs-opsiclear-quel) [pinterest-p icon](http://pinterest.com/pin/create/link/?url=https://blog.quelimaging.com/3dgs-opsiclear-quel) [envelope icon](mailto:?body=https://blog.quelimaging.com/3dgs-opsiclear-quel) This week, we shared a five-day series of 3D Gaussian splats created in collaboration with [OpsiClear](https://www.opsiclear.com/), who have been developing an advanced 3D Gaussian Splatting (3DGS) pipeline to transform clinical specimens and physical phantoms into detailed, true-to-life digital twins. At QUEL Imaging, this work aligns closely with [our mission](https://www.quelimaging.com/about): to advance quantitative fluorescence imaging by creating phantoms and simulation tools that tightly couple physical measurements with computational modeling. Well-characterized 3D models — when paired with [Monte Carlo simulations](https://pubmed.ncbi.nlm.nih.gov/40443945/) — become the backbone of powerful digital twins that can accelerate system design, performance testing, and translational research. Below is a recap of the modeling technology, along with insights into how 3DGS fits into our broader vision for hybrid physical–digital phantoms. | | | --- | | Interactive Depth Target 3DGS | | | | Interactive Mouse Phantom 3DGS | ## Why 3D Gaussian Splatting Matters for Phantom Development 3D Gaussian Splatting offers a fast, flexible way to create dense, photorealistic 3D reconstructions from real objects. For optical phantom development, this presents several key advantages: - **Capturing geometry with high fidelity:** Phantoms often encode anatomical or structural details that matter for optical behavior. 3DGS preserves these fine features - **Providing realistic visualization and interactive exploration:** Researchers and system designers can view phantoms from any angle, examine structural complexity, and understand light paths intuitively. - **Supporting digital twin workflows:** When combined with QUEL Imaging’s Monte Carlo fluorescence simulations, 3DGS-derived meshes become the foundation for predictive modeling — merging the physical and virtual domains. - **Accelerating system development:** Digital-first prototyping (via splats + simulations) helps teams evaluate imaging performance before building physical prototypes, improving both speed and iteration quality. This week’s splats highlighted these concepts across a range of phantom geometries, from simple performance targets to complex organ models. | | | --- | | Interactive 3DGS of the Prototype FluoFlow® Colon Phantom | | | | Design concept and demonstration of the Prototype FluoFlow® Colon Phantom | ## 🔬 Spotlight: QUEL’s FluoFlow**®** Product Line Our [FluoFlow**®**](https://shop.quelimaging.com/product/fluoflow/) platform is designed to introduce dynamic fluorescence behavior into tissue-mimicking phantoms. Instead of static fluorophores or embedded targets alone, FluoFlow**®** allows researchers to: - simulate blood flow, perfusion, and in-flow/out-flow kinetics - evaluate dynamic imaging performance, including temporal sensitivity and motion-related artifacts - test quantitative fluorescence imaging algorithms under controlled, reproducible flow conditions - integrate dynamic experiments with Monte Carlo simulations for hybrid digital-physical studies The Colon FluoFlow® Phantom featured on Friday is a perfect example: a colon-mimicking optical structure paired with controlled flow channels to evaluate fluorescence signal dynamics in real time. Paired with 3D Gaussian Splatting, FluoFlow® systems can be reconstructed as 3D digital twins, enabling simulation-driven design iteration, dynamic modeling, and advanced visualization — all from the same physical phantom. ## Closing Thoughts This week’s collaboration with OpsiClear gave us a glimpse of what’s possible when physical phantoms and advanced 3D representations converge. Whether for visualization, simulation, or developing digital twins, 3D Gaussian splats offer a powerful complement to our optical phantom technologies. We’re excited to continue exploring the intersection of well-characterized physical models, 3D reconstruction, and computational simulation — and to keep sharing what we discover along the way. Please let us know how we can help accelerate your clinical translation by [reaching out!](https://shop.quelimaging.com/resources/#contact) [concepts](https://blog.quelimaging.com/tag/concepts), [fluorescencefriday](https://blog.quelimaging.com/tag/fluorescencefriday), [clinical translation](https://blog.quelimaging.com/tag/clinical-translation) ## Related posts [![Fluorescence image of an ICG-equivalent concentration sensitivity phantom](https://blog.quelimaging.com/hs-fs/hubfs/Log_concentration_example_crop.png?height=200&name=Log_concentration_example_crop.png)](https://blog.quelimaging.com/performance-evaluation-for-fgs-systems-phantoms) [standardization](https://blog.quelimaging.com/tag/standardization) ## [Performance Evaluation for FGS Systems: Phantoms](https://blog.quelimaging.com/performance-evaluation-for-fgs-systems-phantoms) ![Picture of Ethan LaRochelle](https://app.hubspot.com/settings/avatar/925081a77283a399dbd145b49b251212) [Ethan LaRochelle](https://blog.quelimaging.com/author/ethan) Jul 14, 2023 10:46:33 AM Two key components of TG311 focus on developing recommendations for measuring clinically-relevant... [Read more](https://blog.quelimaging.com/performance-evaluation-for-fgs-systems-phantoms) [![QUEL Imaging's Skin Tone Multi-material Phantom](https://blog.quelimaging.com/hs-fs/hubfs/Screenshot%202025-10-27%20at%209.37.18%20AM.png?height=200&name=Screenshot%202025-10-27%20at%209.37.18%20AM.png)](https://blog.quelimaging.com/optiblox-qx-overview) [optical properties](https://blog.quelimaging.com/tag/optical-properties), [tissue optics](https://blog.quelimaging.com/tag/tissue-optics), [optiblox](https://blog.quelimaging.com/tag/optiblox) ## [Heterogeneous Optical Tissue Phantoms using Multi-Material Manufacturing](https://blog.quelimaging.com/optiblox-qx-overview) ![Picture of The QUEL Team](https://blog.quelimaging.com/hs-fs/hubfs/QUEL_Q.png?width=50&name=QUEL_Q.png) [The QUEL Team](https://blog.quelimaging.com/author/quel) Oct 27, 2025 5:30:00 AM Traditional optical phantoms have limitations. They're homogeneous blocks of material with uniform... [Read more](https://blog.quelimaging.com/optiblox-qx-overview) [![Use of Phantoms for common applications](https://blog.quelimaging.com/hs-fs/hubfs/PhantomsOverview.png?height=200&name=PhantomsOverview.png)](https://blog.quelimaging.com/tissue-optical-phantoms-essential-tools-for-advancing-fgs) [concepts](https://blog.quelimaging.com/tag/concepts) ## [Tissue Optical Phantoms: Essential Tools for Advancing FGS](https://blog.quelimaging.com/tissue-optical-phantoms-essential-tools-for-advancing-fgs) ![Picture of Ethan LaRochelle](https://app.hubspot.com/settings/avatar/925081a77283a399dbd145b49b251212) [Ethan LaRochelle](https://blog.quelimaging.com/author/ethan) Nov 12, 2024 3:30:37 PM Fluorescence-guided surgery (FGS) gives surgeons enhanced precision by illuminating specific... 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Main St. Suite 142 White River Junction, VT, USA Copyright © 2026, QUEL Imaging ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Ethan LaRochelle", "url" : "https://blog.quelimaging.com/author/ethan" }, "dateModified" : "2025-11-14T20:19:13.587Z", "datePublished" : "2025-11-14T15:45:00.000Z", "headline" : "3D Gaussian Splatting and Future Digital Twins", "image" : [ "https://blog.quelimaging.com/hubfs/QUEL_FluoFlowColon.gif" ], "mainEntityOfPage" : { "@id" : "https://blog.quelimaging.com/3dgs-opsiclear-quel", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.quelimaging.com/hubfs/QUEL_Q.png" }, "name" : "QUEL Imaging" } } ```